Thursday, May 23, 2013

H. pylori, smoking trends, and gastric cancer in US men

May 21, 2013 ? The contribution of H. pylori and smoking trends to the decline in gastric cancer in US men.

Trends in Helicobacter pylori (H. pylori) and smoking explain a significant proportion of the decline of intestinal-type noncardia gastric adenocarcinoma (NCGA) incidence in US men between 1978 and 2008, and are estimated to continue to contribute to further declines between 2008 and 2040.

These are the conclusions of a study by Jennifer M. Yeh of the Center for Health Decision Science at the Harvard School of Public Health in Boston and colleagues, published in this week's PLOS Medicine, that suggest H. pylori and smoking trends together accounted for almost half of the observed decline in intestinal-type NCGA between 1978 and 2008. Understanding the combined effects of underlying risk factor trends on health outcomes for intestinal-type NCGA at the population level can help to predict future cancer trends and burden in the US.

The researchers developed a population-based microsimulation model using risk factor data from two national databases, the National Health and Nutrition Examination Survey (NHANES) and National Health Interview Survey (NHIS), and cancer data from the Surveillance, Epidemiology and End Results (SEER) Program. They estimated that the incidence of intestinal-type NCGA in men fell by 60% between 1978 and 2008. Further analysis suggested that H. pylori and smoking trends are responsible for 47% of the observed decline, and that H. pylori trends alone were responsible for 43% of the decrease in cancer but smoking trends were responsible for only a 3% drop. Finally, the researchers projected the incidence of intestinal-type NCGA to decline an additional 47% between 2008 and 2040, with H. pylori and smoking trends accounting for more than 81% of the observed fall. Key limitations to this study include the assumptions made in the model and that the study only examined one type of gastric cancer (GC) and focused only on men.

The authors say: "In conclusion, trends in modifiable risk factors explain a significant proportion of the decline of intestinal-type NCGA incidence in the US, and will contribute to future decline."

They add: "Although past tobacco control efforts have hastened the decline, the full benefits will take several decades to be realized, and further discouragement of smoking and reduction of H. pylori infection should be priorities for GC control efforts."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/xvzVNGNOfwo/130521193954.htm

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Wednesday, May 22, 2013

Charlotte Casiraghi enjoys game of football

22 MAY 2013

Monegasque royal Charlotte Casiraghi was spotted enjoying a game of football in Monaco on Wednesday. Despite wearing heels,?the model?looked to be having a ball as she had a kick around with her brother Andrea.

She paired her wedge cork heels with a blue blazer, white shirt and tight blue denim jeans. The outfit was very similar to the dressed-down ensembles Kate Middleton normally opts for.

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CLICK ON PHOTO FOR FULL GALLERY

The royals were attending the World Stars Football Match, which saw the Star Team Monaco take on Formula One Drivers at Louis II Stadium in Monte Carlo.

Andrea and his beautiful fianc?e Tatiana Santo Domingo recently made their first public appearance since welcoming their first child into the world.

The couple, who became parents for the first time in March when Tatiana gave birth to a baby boy, stepped out for the Dior Cruise show in Monaco on Sunday.

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The glowing new mum beamed as she turned up to the fashion event with her equally happy fianc?. She had opted to cover up in a red cape and baggy black trousers. Andrea, meanwhile, was dapper in a blue suit and red tie.

Andrea and Tatiana became parents back in March. Princess Caroline's press office confirmed the news via a statement. "Her Serene Highness Princess Caroline has the pleasure of announcing the birth of her grandson, born on 21 March 2013," the missive said. "Both mother and baby are doing well".

The newest member of the Grimaldi clan isn't a potential successor to the Monegasque throne given that Andrea and Tatiana have yet to marry. Any future heir will be the child born to Prince Albert and his wife Charlene.

The arrival of a royal baby in Monaco normally merits some fanfare: For Princess Caroline's baptism in 1957, four bishops and 15 priests presided. The ceremony took place amid the splendour of the principality's cathedral, which had been filled with 10,000 lilies and tulips for the occasion.

But new mum Tatiana's style is more low-key, and such a lavish display of pomp and circumstance is unlikely to surround her first child.

Instead, the family base will be in Paris, far away from the media spotlight. It was there that Andrea and his fianc?e first fell in love while studying.

Tatiana is the granddaughter of the late Colombian mega-mogul Julio Santo Domingo, and is set to inherit an estimated $6bn fortune which she will share with her younger brother Julio Mario Santo Domingo III.

Despite her vast wealth she has worked hard to establish ethical fashion brand Muzungu Sisters, which she co-founded with business partner Dana Alikhani, daughter of the late Iranian businessman Hossein Alikhani.

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Source: http://www.hellomagazine.com/royalty/2013052212717/charlotte-casiraghi-monaco-football/

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Arias speaks out about case in jailhouse interview

PHOENIX (AP) ? In a surprise jailhouse interview just hours after a jury began deliberating her fate, Jodi Arias spoke out Tuesday about her murder trial, her many fights with her legal team and her belief that she "deserves a second chance at freedom someday."

Arias spoke to The Associated Press as part of a series of interviews with media outlets. She repeated many of her claims from previous interviews, testimony on the witness stand and her statements to the jury earlier Tuesday as she pleaded for mercy.

But she provided some new information about her case and how she believed her lawyers let her down by not calling more witnesses who could have bolstered her claims that she was a victim of domestic violence at the hands of Travis Alexander.

Arias was convicted last week of first-degree murder in the June 2008 stabbing and shooting death of her one-time lover in what prosecutors described as a cold, calculated killing carried out in a jealous rage. Arias has maintained all along it was self-defense.

The jury began deliberating Tuesday as they worked to determine whether she should live or die for her crime. If the jury opts for a life sentence, the judge will have the option of determining whether she spends the rest of her days behind bars or is eligible for release after 25 years. Arias acknowledged it was unlikely she would ever be released, but believed she deserves a second chance.

Following her conviction last week, she told a local TV station that she preferred the death penalty. She said Tuesday night that she changed her mind after a tearful meeting with family members that same day, realizing that her death would only cause them more pain.

"I felt like by asking for death, it's like asking for assisted suicide and I didn't want to do that to my family," she told the AP.

Arias said she fought from the beginning to keep cameras out of the courtroom to limit the media spectacle, and believes that the jury should have been sequestered. She stated flatly that she did not receive a fair trial.

"The prosecutor has accused me of wanting to be famous, which is not true," she said.

However, Arias has sought the spotlight at every turn, providing TV interviews and even using a third-party to tweet throughout the trial.

Arias repeated her claims that she never wanted to go to trial in the first place but instead wanted to reach a deal with prosecutors on a second-degree murder count that would have carried a maximum of 22 years in prison. However, she said, "no deal was offered."

She gave the interviews Tuesday after the judge lifted an order barring jail officials from arranging any media requests. The judge did not elaborate on the reason for the ruling, but Maricopa County Sheriff Joe Arpaio's office quickly began making the media arrangements that lasted late into the night.

A shackled Arias wore makeup for the interviews and showed up in a jail classroom with a comb in hand as she fixed her hair for the cameras. When pressed for details on some of her conflicting stories, she was mostly evasive, citing advice from her attorneys and possible pending appeals.

She was also asked about the conflicts she had had with her two court-appointed lawyers, Kirk Nurmi and Jennifer Willmott.

Arias said she wanted at least three people called as witnesses who could have testified to having seen bruises on her neck "when I was choked out" by Alexander but she said she was rebuffed by her lawyers. The prosecutor insisted her claims of self-defense were an exaggerated attempt to avoid being convicted.

She said her lawyers "felt a little betrayed" and blindsided by her post-conviction interview but that they gave their blessings for Tuesday night's interviews, warning her to be cautious.

Arias said she sometimes wishes she'd never met Alexander, "just because of how ultimately everything ended and I say that for his sake and mine ? not just a selfish thing."

She said if the attack never occurred and she never crossed paths with the victim, she would likely now be a happily married 32-year-old with children, good finances and a successful wedding photography business.

Earlier Tuesday, Arias told jurors she planned to use her time in prison to bring about positive changes, including donating her hair to be made into wigs for cancer victims, helping establish prison recycling programs and designing T-shirts to raise money for domestic abuse victims.

Arias became emotional as she displayed for jurors photos of her friends, boyfriends and family members, including newborn relatives she has met only from behind bars.

She asked jurors to reject the death penalty for the sake of her family.

"I'm asking you to please, please don't do that to them. I've already hurt them so badly, along with so many other people," she said. "I want everyone's healing to begin, and I want everyone's pain to stop."

Arias stabbed and slashed Alexander nearly 30 times, shot in him in the forehead and slit his throat, nearly decapitating him, before leaving his body in his shower to be found by friends about five days later.

"To this day, I can hardly believe I was capable of such violence. But I know that I was," Arias told jurors. "And for that, I'm going to be sorry for the rest of my life."

Her speech to jurors came a day after her attorneys asked to be removed from the case, saying the five-month trial had become a witch hunt that prompted death threats against a key witness in the penalty phase. They also argued for a mistrial. The judge denied both requests.

Alexander's family showed little emotion as Arias' mother, father and sister looked on from the other side of the gallery and cried.

After Arias finished speaking, Judge Sherry Stephens explained to jurors that their finding would be final.

The jury heard closing arguments later Tuesday, with Willmott citing Arias' mental health problems and lack of a criminal record among the reasons to spare her life.

"The question now before you is: Do you kill her? Do you kill her for the one act that she did, the one horrible act, or can you see that there is a reason to let her live? Can you see that there is value in her life?" she said.

Prosecutor Juan Martinez said that despite Arias' claims, there were no factors in the case that would warrant a sentence other than death.

He implored jurors to look at the "whole panorama" of the case, not just Arias' statement Tuesday, and explained how Alexander's family will live with the pain of their loss for the rest of their lives.

"They can't forget that what happened on that afternoon, Travis Victor Alexander suffered immense physical pain," Martinez said. "They can't forget that."

Source: http://news.yahoo.com/arias-speaks-case-jailhouse-interview-055458185.html

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While you were focused on the IRS, DC pols just sunk us DEEPER into debt

??? ??? Publisher's: Brant Clifton examines the embarrassment of the the scandal ridden Obama Administration in his "bare knuckles" Conservative online publication known as The Daily Haymaker.

??? Outrageous. The IRS was asking a religious non-profit about the substance of its prayers. Outrageous. A Christian mentoring organization was asked about the specific backgrounds of the students it mentors. Outrageous. (Do Al Sharpton, Jesse Jackson or Bill Barber get scrutinized like this? Hell, NO.)

??? While members of Congress got lots of great face-time on the mainstream media - verbally abusing the IRS - the administration quietly sunk our nation deeper into debt:

??? On May 19, the United States hit its debt ceiling after adding $300 billion in more debt since lawmakers suspended the ceiling in February.

??? But the cash won't run dry until at least Labor Day, according to Treasury Secretary Jack Lew, whose department can employ a variety of cash management tools to continue spending beyond the official debt deadline.

??? Congress last hit the debt ceiling in January. The President and Congress then decided to "suspend" the debt limit through May 18. This is the first time that lawmakers adopted a debt ceiling date instead of a dollar amount. The Congressional Budget Office explains:

??? On May 19, the debt limit will be raised to its previous value - $16.394 trillion - plus the amount of borrowing that occurred while the limit was suspended (that is, from early February to May 18).

??? In other words, the President and Congress decided in February that they would continue borrowing through May 18, with the new debt limit becoming the then-current limit of $16.394 trillion plus whatever was added on since then. Washington racked up $300 billion in more debt in less than four months, making the current limit $16.7 trillion.

??? This is the pattern of recurrent budget negotiation crises:

??? Spend;

??? Spend some more;

??? Run up against the debt ceiling;

??? Resort to "extraordinary measures" to ward off a possible default for a while; and finally,

??? Settle for inadequate measures that fail to curb soaring debt in the future.

??? [...]

??? As the failed super committee negotiations (which resulted in the all-around-hated sequestration) demonstrated, lawmakers need to put in law real policy changes to the entitlement programs, and not push off tough decisions to a new committee that's doomed to fail from the get-go.

??? [...]

??? Our nation is on a dangerous fiscal course, and the debt ceiling is lawmakers' opportunity to grab the oars and steer us out of the coming debt storm.

??? The IRS scandal demonstrates the propensity for big government to harrass, and violate the rights of, average Americans. We still haven't figured out what exactly was going on in Benghazi. One thing we have learned from that affair is that its a 50-50 proposition whether our government will come to the defense of Americans under fire by foreign hostiles.

??? The whole debt thing - if serious action is not taken - will bring our nation down. It doesn't need to be swept off the stage. It needs to be front and center. It needs to be dealt with NOW.

Source: http://beaufortcountynow.com/post/7530/while-you-were-focused-on-the-irs-dc-pols-just-sunk-us-deeper-into-debt.html

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PAC Plus polls Latinos in Texas (Offthekuff)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/307228738?client_source=feed&format=rss

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Watch Microsoft's Xbox Reveal Event Live Right Here, See The Future Of Console Gaming

Screen Shot 2013-05-21 at 7.00.07 AMMicrosoft is about to unveil the next Xbox home gaming console, and they're broadcasting the entire event live for all to watch. There will be thrills! Spills! Chills! Maybe some actual hardware, unlike at Sony's PlayStation 4 reveal. Check it out above, or if you're in an environment where you can't listen in, or just prefer glorious words written by Greg Kumparak to these newfangled moving pictures, check out our live blog.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/rzgT0gXdkIk/

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CSN: Reliant to get upgrades before Super Bowl LI

The Super Bowl is coming back to Houston in 2017.

On Tuesday, NFL owners decided that Super Bowl LI will be at Reliant Stadium. Houston beat out Miami for the big game in 2017. Miami lost to San Francisco to host Super Bowl L in 2016. The loser of that one (Miami) faced Houston for the game the next season.

?I can?t tell you how excited I am for Houston in being selected as the site for the 2017 Super Bowl,? Texans owner Bob McNair said. ?This is a worldwide stage that will be constructed in Houston and the world will be watching. It?s an opportunity to showcase our wonderful city, the NFL and the Super Bowl all at the same time.?

This will be the first time Houston will host the Super Bowl since 2004.

?Yeah. That?s pretty cool,? Texans head coach Gary Kubiak said after practice on Tuesday. ?I know there?s been a tremendous amount of work put in by our organization and Mr. McNair. I know that the city was a tremendous host back years ago, of course I wasn?t here at that time. I know they?ll do a great job again.?

Houston beat Miami and its experience. Miami has hosted the event 10 times, tied with New Orleans for the most times of any city.

"It's a happy moment for us," McNair said on NFL Network. "We had a wonderful time in 2004 and we loved having the NFL in Houston and celebrating the Super bowl."

In early May, lawmakers did not approve a deal to provide taxpayer support for $350 million worth of upgrades to Sun Life Stadium in Miami. That doomed the city's chances of hosting either Super Bowl.

?Certainly what happened doesn?t help Miami?s bid,? McNair said a few days after that news came out.

In mid-April, the Texans hosted NFL Senior Vice President of Events Frank Supovitz. Supovitz was in town to tour the city and help strengthen Houston's bid.

One notable addition to Reliant Stadium will be extra-wide video boards on either side of the field. These boards will be ready for use this season but also helped make the bid stronger.

NFL Network asked McNair if he enjoyed telling Jerry Jones that his new video boards would be bigger than the one in Dallas. "Yeah but I didn't tell him about that until after he voted," McNair said.

The Houston Super Bowl Committee was led by chairman Ric Campo. The honorary chairman, James Baker, was not allowed to be a part of the presentation because the league deemed him a celebrity. But Baker still helped to build the bid.

?The Super Bowl brings an enormous economic impact to its host city,? Campo said in late February. ?It also offers us a chance to show a worldwide television audience what a vibrant and international city Houston truly is.?

The Super Bowl committee was composed of 15 community leaders and according to a release from the Texans earlier in the year, the city saw an economic impact of more than $350 million when it hosted Super Bowl XLVII in 2004. ?

?We?ve accomplished what we set out to do,? Campo said. ?Thanks to the support and efforts of Mayor Parker, Judge Emmett and the entire Houston Bid Committee, we?re bringing another Super Bowl back to Houston. Our plans for the international celebration leading up to the game will create an unprecedented fan experience for Super Bowl LI.?

Next year's Super Bowl will be held in New York, the first time the game will be held in a cold-weather city. If that goes well, other places like Washington, Philadelphia and Chicago will likely bid for future games.

The Super Bowl in 2015 will be in the Phoenix area.

Source: http://www.csnhouston.com/football-houston-texans/talk/houston-will-host-super-bowl-2017

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Editorial: Engadget on the Xbox One

Editorial Engadget on the Xbox One

At long last, Microsoft unveiled its next-generation gaming console today, the Xbox One. As expected, its hardware stacks up well with the Wii U and PlayStation 4, and the launch event showcased some slick new software, too. With tight fantasy sports integration, Windows 8 and Skype support and cooperation with live TV, the One looks to have taken the next step in transforming the Xbox from a gaming rig into a true home entertainment console. It's a rare thing to get to opine on a new game console, so head on past the break and allow us to indulge this opportunity.

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Source: http://www.engadget.com/2013/05/21/editorial-xbox-one/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Helios handlebars add LED blinkers, GPS and more to any bike (hands-on)

Helios handlebars turns any bike into a smart twowheeler handson

Technologically bent cyclists have their choice of advanced bicycles these days, but it's a little hard to justify getting a specialized vehicle if your existing two-wheeler still functions just fine. However, swap your bike's handlebars with one of these handsome aluminum ones from Helios and all of a sudden your beloved ride is equipped with a 500-lumen headlight, a pair of rear-facing RGB LED indicators, Bluetooth 4.0 for smartphone communications and, yes, even a built-in GPS. Join us after the break as we give you a brief tour of the Helios Bars and how it's well worth its $200 price point.

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Source: http://www.engadget.com/2013/05/20/helios-handlebars/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Tuesday, May 21, 2013

Andrew Garfield: Balling with Kids as Spider-Man?

Source: http://www.thehollywoodgossip.com/2013/05/andrew-garfield-balling-with-kids-as-spider-man/

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Get regular screenings for colorectal cancer | In The News

Did you know colorectal cancer is the second leading cause of cancer-related deaths in the United States among cancers that affect both men and women? If everyone 50 or older got screened regularly, as many as 60% of deaths from this cancer could be avoided.

In most cases, colorectal cancer develops from precancerous polyps (abnormal growths) in the colon or rectum. Fortunately, screening tests can find these polyps, so you can get them removed before they turn into cancer. Screening tests also can find colorectal cancer early, when treatment works best.

It?s National Colorectal Cancer Awareness Month ? do what you can to reduce?your?risk for colorectal cancer. If you?re 50 or older, or have a personal or family history of colorectal issues, make sure you get screened for colorectal cancer regularly. Don?t worry about the cost?Medicare covers a variety of?colorectal cancer screenings, and you pay nothing for most tests.

Source: http://in-the-news.net/get-regular-screenings-for-colorectal-cancer/

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NASA Mars rover Curiosity drills second rock target

May 20, 2013 ? NASA's Mars rover Curiosity has used the drill on its robotic arm to collect a powdered sample from the interior of a rock called "Cumberland."

Plans call for delivering portions of the sample in coming days to laboratory instruments inside the rover. This is only the second time that a sample has been collected from inside a rock on Mars. The first was Curiosity's drilling at a target called "John Klein" three months ago. Cumberland resembles John Klein and lies about nine feet (2.75 meters) farther west. Both are within a shallow depression called "Yellowknife Bay."

The hole that Curiosity drilled into Cumberland on May 19 is about 0.6 inch (1.6 centimeters) in diameter and about 2.6 inches (6.6 centimeters) deep.

The science team expects to use analysis of material from Cumberland to check findings from John Klein. Preliminary findings from analysis of John Klein rock powder by Curiosity's onboard laboratory instruments indicate that the location long ago had environmental conditions favorable for microbial life. The favorable conditions included the key elemental ingredients for life, an energy gradient that could be exploited by microbes, and water that was not harshly acidic or briny.

NASA's Mars Science Laboratory Project is using Curiosity to assess the history of habitable environmental conditions inside Gale Crater. After a few more high-priority observations by the rover within and near Yellowknife Bay, the rover team plans to start Curiosity on a months-long trek to the base of a layered mound, Mount Sharp, at the middle of the crater. JPL, a division of the California Institute of Technology in Pasadena, manages the project for NASA's Science Mission Directorate in Washington.

More information about Curiosity is online at http://www.jpl.nasa.gov/msl , http://www.nasa.gov/msl and http://mars.jpl.nasa.gov/msl/ . You can follow the mission on Facebook at: http://www.facebook.com/marscuriosity and on Twitter at: http://www.twitter.com/marscuriosity .

Source: http://feeds.sciencedaily.com/~r/sciencedaily/space_time/nasa/~3/B0Lxli31_qY/130520173205.htm

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Earth's iron core is surprisingly weak

May 20, 2013 ? Researchers have used a diamond anvil cell to squeeze iron at pressures as high as 3 million times that felt at sea level to recreate conditions at the center of Earth. The findings could refine theories of how the planet and its core evolved.

Through laboratory experiments, postdoctoral researcher Arianna Gleason, left, and Wendy Mao, an assistant professor of geological and environmental sciences and of photon science, determined that the iron in Earth's inner core is about 40 percent as strong as previously believed.

The massive ball of iron sitting at the center of Earth is not quite as "rock-solid" as has been thought, say two Stanford mineral physicists. By conducting experiments that simulate the immense pressures deep in the planet's interior, the researchers determined that iron in Earth's inner core is only about 40 percent as strong as previous studies estimated.

This is the first time scientists have been able to experimentally measure the effect of such intense pressure -- as high as 3 million times the pressure Earth's atmosphere exerts at sea level -- in a laboratory. A paper presenting the results of their study is available online in Nature Geoscience.

"The strength of iron under these extreme pressures is startlingly weak," said Arianna Gleason, a postdoctoral researcher in the department of Geological and Environmental Sciences, and lead author of the paper. Wendy Mao, an assistant professor in the department, is the co-author.

"This strength measurement can help us understand how the core deforms over long time scales, which influences how we think about Earth's evolution and planetary evolution in general," Gleason said.

Until now, almost all of what is known about Earth's inner core came from studies tracking seismic waves as they travel from the surface of the planet through the interior. Those studies have shown that the travel time through the inner core isn't the same in every direction, indicating that the inner core itself is not uniform. Over time and subjected to great pressure, the core has developed a sort of fabric as grains of iron elongate and align lengthwise in parallel formations.

The ease and speed with which iron grains in the inner core can deform and align would have influenced the evolution of the early Earth and development of the geomagnetic field. The field is generated by the circulation of liquid iron in the outer core around the solid inner core and shields Earth from the full intensity of solar radiation. Without the geomagnetic field, life -- at least as we know it -- would not be possible on Earth.

"The development of the inner core would certainly have some effect on the geomagnetic field, but just what effect and the magnitude of the effect, we can't say," said Mao. "That is very speculative."

Gleason and Mao conducted their experiments using a diamond anvil cell -- a device that can exert immense pressure on tiny samples clenched between two diamonds. They subjected minute amounts of pure iron to pressures between 200 and 300 gigapascals (equivalent to the pressure of 2 million to 3 million Earth atmospheres). Previous experimental studies were conducted in the range of only 10 gigapascals.

"We really pushed the limit here in terms of experimental conditions," Gleason said. "Pioneering advancements in pressure-generation techniques and improvements in detector sensitivity, for example, used at large X-ray synchrotron facilities, such as Argonne National Lab, have allowed us to make these new measurements."

In addition to intense pressures, the inner core also has extreme temperatures. The boundary between the inner and outer core has temperatures comparable to the surface of the sun. Simultaneously simulating both the pressure and temperature at the inner core isn't yet possible in the laboratory, though Gleason and Mao are working on that for future studies. (For this study, Gleason mathematically extrapolated from their pressure data to factor in the effect of temperature.)

Gleason and Mao expect their findings will help other researchers set more realistic variables for conducting their own experiments.

"People modeling the inner core haven't had many experimental constraints, because it's so difficult to make measurements under those conditions," Mao said. "There really weren't constraints on how strong the core was, so this is really a fundamental new constraint."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/uYHvEXbKtnY/130520095404.htm

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Belmont Stakes: Oxbow vs. Orb in the cards

BALTIMORE (AP) ? Another year, another Triple Crown hopeful unable to come through.

After Oxbow upset Kentucky Derby winner Orb in Saturday's Preakness to extend racing's Triple Crown drought to 36 years, the next best alternative for the Belmont Stakes is a rematch.

And, it appears one is in the making. Both trainers are giving every indication their classic-winning colts will run in the Belmont on June 8.

"You know me," Hall of Fame trainer D. Wayne Lukas said after Oxbow's 1 ?-length victory over Itsmyluckyday, with 3-5 favorite Orb finishing fourth. "I like to rack them up in the big events. So, I'll probably go."

Trainer Shug McGaughey says he'd like to run Orb in the Belmont as long as the colt is doing well.

"The Belmont Stakes is on our radar screen," McGaughey said Sunday after arriving back at Belmont Park and checking on his Derby winner, who was vanned back earlier in the day.

After a talk with Orb's owners Ogden Mills "Dinny" Phipps and Stuart Janney III, McGaughey said, "We just all came to the conclusion that we should just watch Orb and see. I think everything is in good shape. We'd like to run.

"But yesterday took a little bit out of him and he's already run five times this year and it's only the middle of May. I'd sure like to have him fresh for Saratoga and a Jim Dandy/Travers kind of a go."

A year ago, there was great anticipation for a Triple try after I'll Have Another won the Derby and Preakness, but the colt was scratched the day before the Belmont because of a tendon injury.

The most recent of 20 rematches between classic winners in the Belmont was two years ago, with Derby winner Animal Kingdom and Preakness winner Shackleford hooking up ? but 24-1 long shot Ruler On Ice pulled the upset.

Hours after Oxbow's win at 15-1 odds gave Lukas his record 14th Triple Crown race win ? and sixth Preakness ? the trainer and his colt where on the road back to Churchill Downs.

If both show up for the 1? -mile Belmont, a formidable lineup of challengers could be waiting. Todd Pletcher has five possible starters: Derby runners Revolutionary (third), Overanalyze (11th) and Palace Malice (12th), as well as a pair of fillies in Dreaming of Julia and Unlimited Budget.

Other possibles include Derby runner-up Golden Soul, Mylute (fifth in the Derby, third in the Preakness), Freedom Child, Power Broker and Code West.

McGaughey was disappointed he couldn't follow up his first Derby win with his first Preakness win, but said, "Winning the Derby was my lifetime dream and we won it. I would have loved to have won yesterday and taken it to the next level."

Lukas, meanwhile, won his first Triple Crown race since 2000, when Commendable won the Belmont. Since that win, Lukas was 0-for-31 in 22 Triple Crown races before Saturday.

"I still enjoy doing this so much," he said. "I don't wake up every day anymore trying to prove I can train a racehorse. When you're younger, you keep trying to prove yourself. I'm very comfortable with where I'm at."

Oxbow, ridden by Hall of Famer Gary Stevens, took the lead just after the start and led every step of the way. Orb never seemed to get into his long-striding running style after leaving from the inside No. 1 post and didn't make a serious run for the lead.

The winning time of 1:57.54 was the slowest since 1961, when Carry Back won in 1:57.60. No matter, it gave Stevens his third Preakness win to go along with his three Derby and three Belmonts wins. Not bad for a guy coming back after a seven-year retirement.

"I can't say that we thought we were going to win," the 50-year Hall of Fame rider said, "but we knew we had a chance to win."

The win was a big one for Calumet Farm, too, the iconic stable being revitalized by new owner Brad Kelley. The stable that produced Triple Crown champions Whirlaway in 1941 and Citation in 1948 won its first classic since Forward Pass took the Preakness in the 1968.

"They're all special because they were with a different client," Lukas said when asked to compare his Preakness wins. "The key is to get one every once in a while for the new guy. We've got a new guy in Brad Kelley at Calumet. And to know he was watching at home and put Calumet, who we all know that name, back on the front pages of the racing publications is very special."

Source: http://news.yahoo.com/belmont-stakes-oxbow-vs-orb-cards-191757754.html

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Monday, May 20, 2013

Study identifies new approach to improving treatment for MS and other conditions

Monday, May 20, 2013

Working with lab mice models of multiple sclerosis (MS), UC Davis scientists have detected a novel molecular target for the design of drugs that could be safer and more effective than current FDA-approved medications against MS.

The findings of the research study, published online today in the journal EMBO Molecular Medicine could have therapeutic applications for MS as well as cerebral palsy and leukodystrophies, all disorders associated with loss of white matter, which is the brain tissue that carries information between nerve cells in the brain and the spinal cord.

The target, a protein referred to as mitochondrial translocator protein (TSPO), had been previously identified but not linked to MS, an autoimmune disease that strips the protective fatty coating off nerve fibers of the brain and spinal cord. The mitrochronical TSPO is located on the outer surface of mitochondria, cellular structures that supply energy to the cells. Damage to the fatty coating, or myelin, slows the transmission of the nerve signals that enable body movement as well as sensory and cognitive functioning.

The scientists identified mitochondrial TSPO as a potential therapeutic target when mice that had symptoms of MS improved after being treated with the anti-anxiety drug etifoxine, which interacts with mitochondrial TSPO. When etifoxine, a drug clinically available in Europe, was administered to the MS mice before they had clinical signs of disease, the severity of the disease was reduced when compared to the untreated lab animals. When treated at the peak of disease severity, the animals' MS symptoms improved.

"Etifoxine has a novel protective effect against the loss of the sheath that insulates the nerve fibers that transmit the signals from brain cells," said Wenbin Deng, principal investigator of the study and associate professor of biochemistry and molecular medicine at UC Davis.

"Our discovery of etifoxine's effects on an MS animal model suggests that mitochondrial TSPO represents a potential therapeutic target for MS drug development," said Deng.

"Drugs designed to more precisely bind to mitochondrial TSPO may help repair the myelin sheath of MS patients and thereby even help restore the transmission of signals in the central nervous system that enable normal motor, sensory and cognitive functions," he said.

Deng added that better treatments for MS and other demyelinating diseases are needed, especially since current FDA-approved therapies do not repair the damage of immune attacks on the myelin sheath.

The UC Davis research team hopes to further investigate the therapeutic applications of mitochondrial TSPO in drug development for MS and other autoimmune diseases. To identify more efficacious and safer drug candidates, they plan to pursue research grants that will enable them to test a variety of pharmacological compounds that bind to mitochondrial TSPO and other molecular targets in experimental models of MS and other myelin diseases.

The journal paper is entitled, "A TSPO ligand is protective in a mouse model of multiple sclerosis."

###

University of California - Davis Health System: http://www.ucdmc.ucdavis.edu

Thanks to University of California - Davis Health System for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/128304/Study_identifies_new_approach_to_improving_treatment_for_MS_and_other_conditions

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Gizmodo and Adhocracy: A Night of Great Conversation at the New Museum

Over the past year, we've thrown a brisket party, a Faux Loko party, and a planetarium party. And on Friday, after we announced some very big news about our new Editor in Chief, we added another unusual party to our list: a dinner in the Skyroom of the New Museum and a tour of the museum's new design exhibition, Adhocracy.

As Gizmodo Managing Editor Brian Barrett mentioned last week, we're broadening our scope to include art, design, and urbanism. So the New Museum, which has staged some of the most interesting shows in recent memory (giant metal slides, anyone?), was a perfect location to celebrate.

First, Curator and Domus Editor Joseph Grima led a walkthrough of Adhocracy, which he describes as "an exhibition about people who make things." 3D-scanned portraits were printed, the latest in wearable tech was sported, and, of course, and libations were consumed. Then, the party moved upstairs to the airy Skyroom of the SANAA-designed museum, where we listened to remarks from Grima, New Museum Director Lisa Phillips, and of course, Gizmodo Editor in Chief Geoff Manaugh. Finally, everyone sat down for dinner, drinks, and good conversation. It was an excellent kick-off celebration for what's to come.

Photos by Victor Jeffreys II (plus a few selfies by our guests).

Geoff Manaugh introduces himself.

An excellent hoodie worn by Gin Lane Media founder Emmett Shine.

Nick Denton; Peter Ha; Tom Plunkett; Brian Barrett; Joel Johnson; and Julia Alvidrez.

Joseph Grima; James Del; Jason Deland; Geoff Manaugh; Heather Corcoran; Iwan Baan.

Emmett Shine; Troy Conrad Thierren; Usman Haque; Samantha Ortega; Shohei Shigematsu; Steven Thomson.

Chad Oppenheim; Chris Barley; Chris Woebken; Alex Mustonen; Alexandra Lange; Anil Dash.

Natalie Jeremijenko; Peter Gerber; Stanley Lumax; Marco Roso; Matt Novak; Moses Gates.

Lauren Cornell; Lisa Phillips; Marc Kushner; Karen Wong; Kristen Becker; Lauren Bertolini.

Julia Kaganskiy; Julie Lasky; Julien De Smedt; Jason Silva; Jesus Diaz; Juergen Mayer H.

Elliott Montgomery; Eva Franch i Gilabert; Fernando Romero; Debbie Kennedy; Dominic Leong; Dror Benshetrit.

Juergen Mayer H. and Fernando Romero.

Asmeret Lumax and Stanley Lumax.

Usman Haque and Natalie Jeremijenko.

Samantha Ortega and Elliott Montgomery.

Source: http://gizmodo.com/gizmodo-and-adhocracy-a-night-of-great-conversation-at-508741584

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Week in review: Google and BlackBerry go iOS, 50 billion app downloads, and more!

Week in review: Google and BlackBerry go iOS, 50 billion app downloads, and more!

It's been a busy, busy week on iMore, and this time the iOS headlines have been dominated by news from ostensibly competing conferences -- BlackBerry Live and Google I/O. The main conversation topic this week was cross platform messaging from BlackBerry and Google both, though also making the headlines was Google's answer to Game Center, Amazon taking on iTunes on the desktop, and the App Store finally hitting 50 billion downloads. Read on for the recap!

The big story early in the week came from BlackBerry Live in Orlando. While we may have expected some news of the enterprise kind that affected iOS devices, we weren't quite prepared for what came next. CEO Thorsten Heins took to the stage and announced that their signature messaging tool, BlackBerry Messenger (BBM) would be coming to iOS this summer. Some see it as too little, too late, but there seems to be a healthy early interest in the product. We'll be looking forward to putting it through its paces later this year. It also now means, as Rene pointed out, that each competing platform owner now makes apps for iOS. Apple by contrast, makes squarely nothing for any of its competitors.

Messaging was the talk of the town over in San Francisco too, at Google I/O. Much-rumored leading up to the conference, Google debuted their new, cross-platform, Google+ Hangouts messaging service, now available on iOS as well as Android and the web. Hangouts seems to amalgamate the existing Hangouts experience of group video chat, with the existing Google Talk instant messaging service. Early impressions are good, but for the complete run down be sure to check out Leanna's full review.

Also coming out of Google I/O was news of an iPad version of Google Maps heading our way this year, updated Google Now cards and Google Play game services. Google's answer to Game Center, the game services API's are going cross-platform and are available to developers of iOS games too. Our own Peter Cohen gave his take on Google's new services following the announcement, so be sure to give it a read.

The third competing platform announcing a move to Apple products this week was Amazon. Until now, Amazon's Cloud Player music service has only been available via the web browser, but the launch of a desktop version takes on Apple's own iTunes. Initially, Cloud Player is only available for Windows PC's, but there is a version for the Mac in the works. This is great news for Amazon MP3 Store customers however, as getting your music onto your Mac and into iTunes isn't the most user friendly experience as it stands.

One piece of big Apple news this week, was the App Store finally reaching its milestone 50 billion downloads. The lucky winner was one Brandon Ashmore, who downloaded Say The Same Thing to win the $10,000 App Store gift card. Congratulations to Brandon!

Elsewhere this week, the iMore staff gave us their thoughts on a variety of subjects. Leanna gave us a sterling round up of the best photography apps for the iPhone, while Peter weighed the pros and cons of all three (!) of Apple's current 13-inch MacBook offerings, and also gave us the arguments against touchscreen Macs . All excellent items well worth reading if you missed them the first time round.

Rene, meanwhile, is still pining on a better way to surface files on iOS. Four years of that and counting. Will Apple finally put him out of his misery?

There you have them, the best of iMore for week. What stood out for you in everything that went on in the last 7 days? What do you still want to comment about? Have at it below!

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/Nf2uwVxEQv4/story01.htm

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Mechanism linking key inflammatory marker to cancer identified

May 20, 2013 ? In a new study described in the journal Oncogene, researchers reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor growth.

Scientists call this Jekyll-and-Hyde molecule NF-kappa B. In healthy cells, it is a powerful "first responder," a vital part of the body's immune and inflammatory responses. It spends most of its life in the cell's cytoplasm, quietly awaiting orders. But when extracellular signals -- of a viral or bacterial invasion, for example -- set off chemical alarms, the cell unchains this warhorse, allowing it to go into the nucleus where it spurs a flurry of defensive activity, including the transcription of genes that trigger inflammation, promote cell proliferation and undermine cell death.

Researchers have known for years that a hyperactive form of NF-kappa B that gets into the nucleus and stays there is associated with various cancers. But they didn't know what was keeping it active in the nucleus.

"Normally in the cell NF-kappa B is in the cytosol, it's not in the nucleus, and it's not activated," said University of Illinois medical biochemistry professor Lin-Feng Chen, who led the new study. "You have to stimulate normal cells to see NF-kappa B in the nucleus. But in cancer cells without any stimulation you can see this nuclear form of NF-kappa B. The cell just won't die because of this. That is why NF-kappa B is so important in cancer."

In the new study, Chen's group found that another molecule known to help regulate gene expression, called BRD4, recognizes a specific amino acid on a subunit of the NF-kappa B protein complex after the amino acid has been marked with a specific tag, called an acetyl group. This "acetylation" allows the BRD4 to bind to NF-kappa B, activating it and preventing its degradation in cancer cells.

Previous studies had shown that BRD4's recognition of the acetylated subunit increased NF-kappa B activation, but this recognition had not been linked to cancer.

BRD4 belongs to a class of molecules that can recognize chemical markers on other proteins and interact with them to spur the marked proteins to perform new tasks. Chemical "readers" such as BRD4 are important players in the field of epigenetics, which focuses on how specific genes are regulated.

"In epigenetics, there are writers, there are readers and there are erasers," Chen said. The writers make modifications to proteins after they are formed, without changing the underlying sequence of the gene that codes for them. These modifications (such as acetylation) signal other molecules (the readers) to engage with the marked proteins in various ways, allowing the proteins to fulfill new roles in the life of the cell. Epigenetic erasers remove the marks when they are no longer of use.

Such protein modifications "have been shown to be critically involved in transcription regulation and cancer development," the researchers report.

To test whether BRD4 was contributing to the sustained presence of NF-kappa B in the nucleus of cancer cells, Chen and his colleagues exposed lung cancer cells in cell culture and in immune-deficient mice to JQ1, a drug that interferes with BRD4 activity. Exposure to JQ1 blocked the interaction of BRD4 and NF-kappa B, blocked the expression of genes regulated by NF-kappa B, reduced proliferation of lung cancer cells and suppressed the ability of lung cancer cells to induce tumors in immune-deficient mice, the researchers found.

The researchers also discovered that depletion of BRD4 or the treatment of cells with JQ1 induced the degradation of the NF-kappa B subunit recognized by BRD4.

Chen said that BRD4 likely prevents other molecules from recognizing the hyperactive NF-kappa B in the nucleus and marking it for degradation.

"This is an example of how epigenetic regulators and NF-kappa B may one day be targeted for the treatment of cancer," he said.

Researchers from Illinois biochemistry professor Satish Nair's laboratory and from the laboratory of James Bradner at the Dana-Farber Cancer Institute contributed to this study.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/gX3-B62y22w/130520095320.htm

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'Puppet-master' Putin advisor is shown the Kremlin door

Vladislav Surkov was once one of the president's most influential and deft advisers. His forced resignation suggests the Kremlin may be pursuing blunter ways of manipulating the political landscape.

By Fred Weir,?Correspondent / May 8, 2013

Kremlin aide Vladislav Surkov speaks before the state of the nation address at the Kremlin in Moscow in this 2011 photo. Surkov, who was once Russian President Vladimir Putin's chief political strategist and dubbed the Kremlin's puppet master, resigned on May 8.

Sergei Karpukhin/Reuters

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Vladislav Surkov, the former theater arts major who took on the job of stage-managing Russian democracy on behalf of Vladimir Putin, was abruptly shown the Kremlin door Wednesday.?Most analysts see the move as a sign that an increasingly heavy-handed Mr. Putin has no further use for Mr. Surkov's elaborate and relatively gentle methods of manipulating the political landscape.

Skip to next paragraph Fred Weir

Correspondent

Fred Weir has been the Monitor's Moscow correspondent, covering Russia and the former Soviet Union, since 1998.?

Recent posts

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Surkov, an influential Putin advisor who helped sculpt Russia's so-called "sovereign democracy" system, told the Moscow daily Kommersant that he had tendered his resignation on April 26, but will only discuss the reasons for his departure "when it is appropriate."

Putin's spokesman, Dmitry Peskov, suggested to the Kommersant FM radio station that he had been pushed out the door due to poor job performance.?

"[His resignation] is related to the high-priority task of implementing presidential decrees," Mr. Peskov said.

Often referred to as the "grey cardinal" of the Kremlin, Surkov's star had been falling since a massive protest movement hit Moscow streets in December 2011. It had been triggered by the near-universal allegations of electoral fraud committed by Surkov's own brainchild ? the pro-Kremlin United Russia party ? in parliamentary polls.

He was subsequently eased out of his role as Putin's deputy chief of staff and given the thankless-by-definition job of deputy prime minister in charge of modernizing Russia's economy.

"His resignation testifies to the fact that there is a real political crisis in the country. Different bureaucratic structures are at war with each other, and Russia is becoming increasingly ungovernable," says Boris Kagarlitsky, director of the independent Institute of Globalization and Social Movement Studies in Moscow. ?

"Surkov had his own vision. He tried to control the process, to reconcile different structures, and he lost," he adds.

Surkov had been a Kremlin fixture since Putin's first presidential term and is widely regarded as the chief architect of the Putin-era system of "sovereign democracy," whose basic idea is that the political system headed by Putin is the direct outgrowth of Russia's own history and public dynamics ? not an import from anywhere else ? and is therefore democracy.

Critics, and even many independent analysts, quickly substituted the more descriptive term "managed democracy."?The phrase evoked the Kremlin's aggressive role in landscaping Russia's political garden ??weeding out pesky opposition parties and independent politicians, concentrating official resources and state media attention behind the ruling United Russia party, and generally altering rules of the game to favor pro-Kremlin outcomes.?

In addition to fathering United Russia, Surkov created a bouquet of pro-Kremlin public organizations, such as the youth movement Nashi and a state-supported assembly of tame civil society groups called the Public Chamber.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/WG6dOY5W4ow/Puppet-master-Putin-advisor-is-shown-the-Kremlin-door

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Sunday, May 19, 2013

Mystery Google media player drops by the FCC

Nexus Q

Could a Nexus Q successor be on the way?

Google's kept pretty quiet about the Nexus Q since removing it from sale last summer. Last we heard, the company was still working on refining its streaming sphere, and that was back in January. In recent days, the lack of Nexus Q support in the new Google Play Music app had led some to believe that Google had abandoned the project. However, freshly-filed FCC documents indicate that Google could be preparing another media player device for release.

The "H840 Device" is revealed in FCC documents to function "as a media player," and was given with the model number H2G2-42, an apparent Hitchhiker's Guide to the Galaxy reference. As is customary for unreleased products, Google has requested that diagrams and photos of the device remain confidential.

Testing documents reveal that it was tested hooked up to a 24-inch Dell monitor, and that it possesses Wifi a/b/g/n support and a USB port. What's more, it gets its power from a separate power supply unit, so we can safely assume this isn't a smartphone, tablet or wearable device.

Google unveiled the ill-fated Nexus Q at least year's Google I/O conference, where attendees were given complementary spheres. The device went up for pre-order shortly afterwards, but before going on sale Google withdrew the device and shipped Qs out to pre-order customers free of charge. Despite being a no-show at this year's I/O, Google's official stance remains that it's "hard at work" improving the multimedia orb. So could this "H840" device be the result of the past year's efforts? We'll have to wait and see.

Source: FCC; via: Liliputing

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/FeqeXTctyZ4/story01.htm

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